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In parallel, excessive Cu + generated in GSH-rich reductive environments can bind lipoylated mitochondrial TCA-cycle proteins such as DLAT, inducing aberrant protein aggregation and triggering cuproptosis across multiple cancer types 187,189,192-194

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Individual Differences in Response to Riboflavin Its important to note that the response to riboflavin supplementation can vary significantly between individuals due to several factors: Genetic variations : Certain genetic polymorphisms, particularly in genes related to flavin metabolism or transport, can affect an individuals response to riboflavin supplementation